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KMID : 0359319850250020145
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Korean Journal of Veterinary Research
1985 Volume.25 No. 2 p.145 ~ p.148
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Nickel Toxicity and Its Interaction with Zinc , Copper and Lead in Growing Chicks
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Abstract
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Nickel toxicity and interactions of nickel with zinc, copper, and lead were studied in glowing chicks fed supplemented diet. Feed intake and growth rate of the chick were reduced by 250㎎ nickel as a sulfate salt per ㎏ of feed. The toxicity of nickel was decreased by zinc or copper supplementation, but not lead. High nickel feed increased nickel level in kidney and decreased zinc levels in tibia and plasma. However, low zinc levels in tibia and in plasma were reversed by zinc supplementation. Hemoglobin, packed cell volume. and aortic elastin content were increased in chicks fed nickel. These results suggest that nickel toxicity is induced by interference with zinc metabolism.
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